Tratamiento del cáncer de próstata con radioterapia por modulación de intensidad, primera experiencia en Chile.

Resumen

INTENSITY MODULATED RADIOTHERAPY TREATMENT FOR PROSTATE CANCER, FIRST EXPERIENCE IN CHILE

Background: Intensity modulated radiotherapy (IMRT) is an important step forward in cancer treatment. Aim: To report the first experience in Chile with IMRT for prostate cancer and compare the results obtained with different doses. Patients and Methods: from January 1997 through June 2008, 156 patients with a mean age of 70 years, were treated with radiotherapy and 121 with IMRT. Patients were staged according to American Commission on Cancer Staging. Their  biochemical relapse risk was classified according to the MD Anderson classification. Patients were routinely checked during and after therapy to evaluate side effects and relapse. Results:  Median follow up was 46 months (4-120). Overall five years survival  was 85%. Biochemical relapse free five years survival  for low, intermediate and high risk patients was 100, 82 and 70%, respectively. Biochemical relapse free survival for patients receiving radiotherapy doses over 76 Gy was 83%, compared to 30% for those receiving lower doses (p<0.05). Urinary and gastrointestinal acute toxicity was low in 80% and 90% of patients respectively. Late toxicity developed in less than 3% of patients. Conclusions: IMRT for prostate cancer   is readily available and safe in Chile.  Biochemical disease free survival improved with higher doses with low toxicity rates.