Asociación de polimorfismos de los genes CRF-BP y SLC6A4 y restricción alimentaria crónica: Un estudio preliminar.

Resumen

CRF-BP AND  SLC6A4  GENE POLYMORPHISMS AMONG RESTRAINED EATERS

Background: Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating. Aim: To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction. Material and methods:  The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively. Results: There was  a significant association between the s/s homozygous genotype for the 5HTTLPR polymorphism of SLC6A4 gene and RE condition (p=0.033). However, this association was not observed for the CRF-BPs11 polymorphism. Conclusions: The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition. (Rev Med Chile…)