Aterosclerosis en sujetos con periodontitis.

Resumen

ASSOCIATION BETWEEN ATHEROSCLEROSIS AND PERIODONTITIS

Background: Chronic inflammation and infections are involved in the development and progression of atherosclerotic vascular disease. Aim: To evaluate the association between periodontitis and early atherosclerosis. Material and Methods: Fifty-three subjects  who received periodontal treatment and regular maintenance for at least 10 years, and 55 subjects with periodontitis but without a history of periodontal treatment were studied. Carotid artery intima-media wall thickness (CIMT) was measured with high-resolution B-mode ultrasonography.  A blood sample was obtained to measure high sensitivity C-reactive protein, fibrinogen, lipoprotein cholesterol, leukocyte count and erythrocyte sedimentation rate. Covariates included  age, gender, smoking, level of education, body mass index and physical activity. The benzoyl-DL-arginine-naphthylamide (BANA) test was used to determine the number of periodontal sites with periodontal pathogens. Results:  CIMT value was significantly higher in subjects with periodontitis than those without it (0.775 ± 0.268 and 0.683 ± 0.131 mm respectively, p=0.027). C-reactive protein, leukocyte count  and percentage of sites with periodontal pathogens  were also significantly higher in subjects with periodontitis. Regression analysis identified age, periodontitis, and smoking as independent predictors of CIMT. Conclusions: These results suggest that untreated periodontitis is associated with early atherosclerotic carotid lesions and higher levels of inflammatory markers.