Encefalitis autoinmune reversible y anticuerpos anti-receptores de N-Metil-D-Aspartato.
Palabras clave:
Limbic encephalitis, Nervous system, Paraneoplastic syndromes, Receptors, N-methyl-D-aspartateResumen
LIMBIC ENCEPHALITIS WITH POSITIVE ANTI-N-METHYL-D-ASPARTATE ANTIBODIES. REPORT OF ONE CASE
Limbic encephalitis is a subacute syndrome characterized by memory impairment, confusion, seizures, hypothalamic dysfunction and psychiatric symptoms. It has been associated to tumors located outside of the central nervous system. In 2007, anti-N-methyl-D-aspartate receptors (NMDAr) antibodies were found in serum and CSF of patients with this particular type of encephalitis. We report a 25 years old female who, following upper respiratory tract symptoms, developed serious behavioral and consciousness impairment that progressed to coma. Cerebrospinal fluid (CSF) analysis showed a lymphocyte pleocytosis, the electroencephalogram was altered with a slow encephalopathic rhythm and a brain magnetic resonance imaging was normal. Infectious etiologies were ruled out. CSF and serum anti NMDA receptors antibodies were positive.
