Evaluación de la Globulina transportadora de Hormonas Esteroidales (SHBG) durante el embarazo como factor predictor de pre-eclampsia y restricción del crecimiento intrauterino.

Resumen

SEX-HORMONE BINDING GLOBULIN (SHBG) LEVELS DURING  PREGNANCY AS PREDICTORS FOR PRE-ECLAMPSIA AND FETAL GROWTH RESTRICTION.

Background:  Sex-Hormone Binding Globulin (SHBG) may be associated to Pre-eclampsia and Fetal Growth Restriction (RCIU). Aim: To determine if maternal serum SHBG concentrations during the first and second trimesters are predictive biomarkers of  Pre-eclampsia and RCIU.  Patients and methods: Prospective cohort study carried out in the Fetal Medicine Unit, University of Chile Clinical Hospital between January, 2005 and December, 2006. Blood samples were obtained from unselected pregnant women during routine 11-14 week and 22-25 week ultrasound examinations, conforming two different study groups. Posteriorly, serum SHBG concentrations were determined in women who developed Pre-eclampsia, RCIU and their respective controls. Results: Fifty five patients were included in the 11-14 weeks group. Nine women that developed PE, 10 that developed RCIU and 36 controls were selected from this group. There were no significant differences in SHBG levels between patients with PE, RCIU or controls (324.7  (26.6),  336.8 (33.9) and 377.5 (24.3) nmol/L, respectively). Fifty four women were included in the  22-25 weeks group. Eight  women who developed Pre-eclampsia, 15 who developed RCIU and 31 controls were selected. Again, there were no significant differences in SHBG levels between patients with PE, RCIU or controls (345.5 (151.1),  383.8 (143.4)  and  345.5 nmol/l (151.1), respectively). Conclusions: Maternal SHBG serum levels did not predict subsequent development of Pre-eclampsia and RCIU.