Agregados amiloides: rol en Desórdenes de Conformación Proteica

Autores/as

  • Claudia Durán-Aniotz University of Texas Health Science Center at Houston
  • Inés Moreno-González University of Texas Health Science Center at Houston
  • Rodrigo Morales University of Texas Health Science Center at Houston

Palabras clave:

Alzheimers disease, Amyloid, Prion diseases, Protein misfolding, Protestasis deficiencies

Resumen

AMYLOID AGGREGATES: ROLE IN PROTEIN MISFOLDING DISORDERS

Misfolding and aggregation of proteins are the main features of a group of diseases termed Protein Misfolding Disorders (PMDs). PMDs include Alzheimer’s disease and Transmissible Spongiform Encephalopathies, among many others. The deposition of protein aggregates is the main responsible for tissue damage and the consequent clinical signs generated in such disorders. In this review, we will focus in the role of protein aggregates in these diseases and in the putative mechanisms by which they exert their toxicity. 

Biografía del autor/a

Claudia Durán-Aniotz, University of Texas Health Science Center at Houston

Claudia Durán-Aniotz Research Assistant I Department of Neurology The University of Texas Health Science Center at Houston 6431 Fannin st. MSE R401 Houston, TX 77030, USA 1-713-500-7493 Claudia.DuranAniotz@uth.tmc.edu

Inés Moreno-González, University of Texas Health Science Center at Houston

Inés Moreno-González Post-doctoral Fellow Department of Neurology The University of Texas Health Science Center at Houston 6431 Fannin st. MSE R401 Houston, TX 77030, USA 1-713-500-7493 Claudia.DuranAniotz@uth.tmc.edu

Rodrigo Morales, University of Texas Health Science Center at Houston

Rodrigo Morales, PhD Post-doctoral Fellow Department of Neurology The University of Texas Health Science Center at Houston 6431 Fannin st. MSE R468 Houston, TX 77030, USA 1-713-500-7442 Rodrigo.MoralesLoyola@uth.tmc.edu

Descargas

Publicado

2013-04-05

Cómo citar

Durán-Aniotz, C., Moreno-González, I., & Morales, R. (2013). Agregados amiloides: rol en Desórdenes de Conformación Proteica. Revista Médica De Chile, 141(4). Recuperado a partir de https://revistamedicadechile.cl/index.php/rmedica/article/view/1946

Número

Vol. 141 Núm. 4 (2013): ABRIL 2013

Sección

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