Caracterización del Metabolismo Oseo Mineral en pacientes con Enfermedad Renal Crónica en Hemodiálisis en el Servicio de Salud Metropolitano Sur, Santiago de Chile.

Resumen

Background: Chronic Kidney Disease - Mineral and Bone Disorder (CKD-MBD) is a condition of dialysis patients associated with both morbidity and mortality. Management is based on clinical guidelines with goals that are hard to comply with. Aim: To describe and compare biochemical variables associated with this disorder in two different time periods. Material and methods: Revision of medical records of 814 patients (49% females) dialyzed during 2009 and 1018 patients (48% females), dialyzed during 2012 in Southern Metropolitan Santiago. Information about serum calcium, phosphorus, parathyroid hormone (PTH) and albumin was retrieved. Results: Median PTH values in 2009 and 2012 were 222.5 and 353.5 pg/ml respectively (p<0.05). The figures for serum calcium corrected by albumin were 9.0 and 8.5 mg/dl respectively (p<0.05). The figures for phosphorus were 4.7 and 5.0 mg/dl respectively (p<0.05). The Calcium x Phosphorus product was 41.4 and 42.5 mg2/dl2 (p<0.05). Of note, the proportion patients with serum calcium below recommended levels (<8.4 mg/dl) increased from 16% to 40% from 2009 to 2012. The proportion of patients with biochemical variables within recommended ranges was lower in 2012 than in 2009. Conclusions: There was a low proportion of patients with bone metabolism parameters within ranges recommended by clinical guidelines. These parameters were worst in 2012.