ASSOCIATION BETWEEN MICRORNA SINGLE NUCLEOTIDE POLYMORPHISMS AND THE RISK OF HEPATOCELLULAR CARCINOMA

Índice h5: 26
Mediana m5: 40

Wenshuai Li; Yanyun Ma; Deqing Zeng; Jun Zhang; Rui Wang; Jingyi Hu; Dongqin Yang; Heping Hu; Juncun Wang; Jie Liu

Autores/as

Wenshuai Li Fudan university
Yanyun Ma Fudan University
Deqing Zeng Fudan University
Jun Zhang Fudan University
Rui Wang Fudan University
Jingyi Hu Fudan University
Dongqin Yang Fudan University
Heping Hu Second Military Medical University
Juncun Wang Fudan University
Jie Liu Fudan University

Palabras clave:

Carcinoma, Hepatocellular, MicroRNAs, Polymorphism, Genetic, Single Nucleotide

Resumen

Background: Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors. Aim: To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples. Material and methods: Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls. Results: A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele. Conclusions: This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC.