Aplasia medular adquirida, experiencia en hospital público de referencia

Autores/as

  • Pilar León Universidad de Chile
  • Daniela Cardemil Universidad de Chile
  • Rocio Osorio Paredes Universidad de Chile
  • Camila Peña Hospital del Salvador
  • Ximena Valladares Hospital del Salvador
  • Bárbara Puga Hospital del Salvador
  • María Elena Cabrera Universidad de Chile Hospital del Salvador

Palabras clave:

Anemia, Aplastic, Homologous, Immunosuppression, Stem Cell Transplantation, Transplantation

Resumen

Background: The first line treatment for patients <40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a donor. Five year overall survival (OS) for both therapies is >70%. Aim: To report the experience with SCT and ATG for AA in a public hospital. Patients and methods: AA was diagnosed in 42 patients between 1998 and 2016, according to Camitta criteria. Thirty eight (90%) received treatment, 7 (18%) under 40 years old received SCT, and 31 (82%) IST. The rest were not treated. OS was calculated from date of diagnosis until last control, death or loss from follow up. Results: Complete or partial hematologic response, was obtained in 71% and 58% of cases with SCT and IS, respectively. Five year OS was 71% and 55% with SCT and IST, respectively. No difference in response was observed between horse and rabbit ATG. Conclusions: SCT from an HLA-identical sibling donor had a high response rate and survival. IST instead, had a lower response and survival, due to an initial high mortality rate.

Biografía del autor/a

Pilar León, Universidad de Chile

Becada Hematología Hospital del Salvador

Daniela Cardemil, Universidad de Chile

Becada Hematología Hospital del Salvador

Rocio Osorio Paredes, Universidad de Chile

Becada Hematología Hospital del Salvador

Camila Peña, Hospital del Salvador

Hematóloga Hospital del Salvador

Ximena Valladares, Hospital del Salvador

Hematóloga Hospital del Salvador

Bárbara Puga, Hospital del Salvador

Jefa de la Unidad Hemato Intensiva, Hospital del Salvador

María Elena Cabrera, Universidad de Chile Hospital del Salvador

Jefa del departamento de Hematología, Hospital del Salvador

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Publicado

2018-01-19

Cómo citar

León, P., Cardemil, D., Osorio Paredes, R., Peña, C., Valladares, X., Puga, B., & Cabrera, M. E. (2018). Aplasia medular adquirida, experiencia en hospital público de referencia. Revista Médica De Chile, 146(2). Recuperado a partir de https://revistamedicadechile.cl/index.php/rmedica/article/view/6072

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Artículos de Investigación

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