Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos.

Autores/as

  • A Verónica Araya hospital clinico universidad de chile y clinica la s condes
  • Daniela Eugenin Hospital Clinico Universidad de Chile
  • Melchor Lemp Hospital Clinico Universidad de Chile y Clínica Las Condes

Palabras clave:

Acromegaly, Cellular Senescence, Pituitary ACTH Hypersecretion, Remission, Spontaneous

Resumen

Pituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. In case 1, acromegaly was diagnosed at 74 years old. Sellar CT scan showed a 10-mm adenoma. During her follow-up, IGF1 levels remained normal. Nine years later, a magnetic resonance (MR) showed a 7-mm adenoma. In case 2, clinical and biochemical diagnosis of Cushing's disease was done at 71 years old. Sellar MR showed a 6-mm adenoma. Three years later, urinary cortisol normalized with no changes in adenoma at MR. Seven years later, she remains without clinical or biochemical signs of hypercortisolism. In both cases, no signs of hemorrhage were observed at MR.

Biografía del autor/a

A Verónica Araya, hospital clinico universidad de chile y clinica la s condes

endocrinologa y diabetologa, seccion endocrinologia y diabetes

hospital clinico Universidad de Chile y Clínica Las Condes

Descargas

Publicado

2018-07-09

Cómo citar

Araya, A. V., Eugenin, D., & Lemp, M. (2018). Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos. Revista Médica De Chile, 146(7). Recuperado a partir de https://revistamedicadechile.cl/index.php/rmedica/article/view/6578

Número

Sección

Reporte de Caso Clínico

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