Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular

Autores/as

  • Juan Pablo Huidobro Espinosa Pontificia Universidad Católica de Chile
  • Ana María Guzmán Pontificia Universidad Católica de Chile
  • Rodrigo Tagle Pontificia Universidad Católica de Chile

Palabras clave:

Cystatin C, Glomerular Filtration Rate, Kidney Function Tests

Resumen

Glomerular filtration rate (GFR) is routinely estimated using endogenous biomarkers due to the complexity of direct measurement methods. Cystatin C is a protease inhibitor produced in all nucleated cells. It is freely filtered and then catabolized by renal tubular cells. Therefore, plasma concentration of cystatin C depends primarily on GFR. Serum cystatin C is less affected by muscle mass, diet, race, gender and age than creatinine. In the general population, equations to estimate GFR based on cystatin C do not have a better performance than those based on creatinine. However, formulas that combine creatinine and cystatin C are more accurate and precise. Estimation of GFR based on cystatin C could be useful in populations in which creatinine value may be biased, such as people with extremely low or high muscle mass, cirrhosis and chronic cardiorenal syndrome. Due to its higher cost in comparison to creatinine, we recommend measuring cystatin C on these clinical situations and when a more accurate estimation of GFR is required.

Biografía del autor/a

Juan Pablo Huidobro Espinosa, Pontificia Universidad Católica de Chile

Departamento de Nefrología

Ana María Guzmán, Pontificia Universidad Católica de Chile

Departamento de de Laboratorios Clínicos

Rodrigo Tagle, Pontificia Universidad Católica de Chile

Departamento de Nefrología

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Publicado

2020-04-06

Cómo citar

Huidobro Espinosa, J. P., Guzmán, A. M., & Tagle, R. (2020). Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular. Revista Médica De Chile, 149(1). Recuperado a partir de https://revistamedicadechile.cl/index.php/rmedica/article/view/8087

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