Determinantes del tiempo puerta- aguja en trombolisis endovenosa en el infarto cerebral, experiencia de un Centro

Resumen

Background: Intravenous thrombolysis (IT) in acute ischemic stroke (AIS) is time dependent. The time elapsed from hospital admission to the thrombolytic bolus is named door to needle time (DNT) and is recommend to be of less than 60 minutes. Aim: To describe the DNT in our center and determine those factors associated with a DNT longer than 60 minutes. Material and methods: Prospective analysis of patients treated with IT at a private hospital between June 2016 and June 2019. The percentage of patients with DNT exceeding 60 minutes, and the causes for this delay were evaluated. Results: IT was used in 205 patients. DNT was 43.6 ± 23.8 minutes. Forty patients (19.5% (95% CI, 14.4–25.7), had a DNT longer than 60 minutes. Uni-varied analysis demonstrated that AIS with infratentorial symptomatology (ITS), was significantly associated with DNTs exceeding 60 minutes. A history of hypertension, a higher NIH Stroke Scale score, the presence of an hyperdense sign in brain tomography (p = 0.001) and the need for endovascular therapy (p = 0.019), were associated with DNT shorter than 60 minutes. Multivariate analysis ratified the relationship between ITS and DNT longer than 60 minutes (Odds ratio: 3.19, 95% confidence intervals 1.26-8). Conclusions: The individual elements that correlated with a DNT longer than 60 minutes were the failure to detect the AIS during triage and doubts about its diagnosis.