Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario

Autores/as

  • Alondra Frías Oyarzún
  • Paula Segura Hidalgo
  • Luis Toro Cabrera
  • Leticia Elgueta Segura
  • Rubén Torres Díaz
  • Miriam Alvo Abodovsky

Palabras clave:

Glomerulonephritis, Membranous, Immunohistochemistry, Immunoglobulin G, Receptors, Phospholipase A2

Resumen

Background: The discovery of the phospholipase A2 receptor antigen and its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis and follow-up of patients with membranous nephropathy (MN). Thus, some international guidelines recommend not performing renal biopsy in patients with positive serum anti-PLA2R Ab. Aim: To evaluate the prevalence of anti-PLA2R Ab in serum and renal tissue samples from Chilean patients with primary MN. Material and methods: Twenty-eight patients aged 50 ± 14 years (20 males) with biopsy-proven primary MN plus a negative workup for secondary causes were included. Measurements of serum and renal histologic anti-PLA2R Ab were performed. The relationship between the findings of serum and tissue anti-PLA2R Ab was evaluated. Results: Fifteen patients (54 %) had anti-PLA2R Ab presence in serum and 19 patients (68%) had positive anti-PLA2R Ab in the renal biopsy. All patients with positive serum anti-PLA2R Ab had positive antibodies on immunohistochemistry. Conclusions: Serum anti-PLA2R Ab is potentially useful in the diagnosis of patients with suspected primary MN in Chilean population.

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Publicado

2020-12-10

Cómo citar

Frías Oyarzún, A., Segura Hidalgo, P., Toro Cabrera, L., Elgueta Segura, L., Torres Díaz, R., & Alvo Abodovsky, M. (2020). Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario. Revista Médica De Chile, 149(1). Recuperado a partir de https://revistamedicadechile.cl/index.php/rmedica/article/view/8393

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