Nueva ecuación para la estimación de la natriuresis diaria a partir de parámetros en plasma y orina aislada en población chilena

Autores/as

  • Rodrigo A Sepúlveda Hospital Clínico Universidad Católica – Red de Salud UC Christus, Departamento de Nefrología, Escuela de Medicina, Facultad de Medicina Pontificia Universidad Católica de Chile.
  • Juan Pablo Huidobro E Hospital Clínico Universidad Católica – Red de Salud UC Christus, Departamento de Nefrología, Escuela de Medicina, Facultad de Medicina Pontificia Universidad Católica de Chile.
  • Aquiles Jara Hospital Clínico Universidad Católica – Red de Salud UC Christus, Departamento de Nefrología, Escuela de Medicina, Facultad de Medicina Pontificia Universidad Católica de Chile.
  • Rodrigo Tagle Hospital Clínico Universidad Católica – Red de Salud UC Christus, Departamento de Nefrología, Escuela de Medicina, Facultad de Medicina Pontificia Universidad Católica de Chile.

Palabras clave:

Diet Therapy, Hypertension, Natriuresis, Sodium Chloride, Urine Specimen Collection

Resumen

Background: Excessive sodium intake is associated with increased cardiovascular morbidity and mortality. Daily sodium intake is usually inferred from sodium excretion in a 24-hour urine collection, which is cumbersome and prone to errors. Different formulas have attempted to estimate 24-hour urinary sodium from a spot urine sample. Unfortunately, their concordancesareinsufficient and have not been tested in our population. Aim: To develop an equation to predict 24-hour urine sodium from parameters in plasma and spot urine samples. To validate the equation and compare it with other formulas in Chilean population.Material and methods: Analysis of 24-hour urine collections, plasma sample and spot urine sample from 174 adult outpatients (81% females) with an estimated glomerular filtration rate (eGFR) ?60 mL/min/1.73m2. These were collected between 2015 and 2019 using standardized methods and educating patients about the correct method to collect 24 h urine samples. In all these patients, creatinine and electrolytes were measured in plasma and urine. A new equation was developed using a multiple linear regression model. Results: Twenty-four-hour urine sodium excretion was significantly correlated with age, weight, height, eGFR, plasma osmolarity, urine electrolytes and parameters obtained from spot urine sample, among others. The new equation had a linear correlation with 24-hour natriuresis of 0.91 and the concordance was 0.9. The predictive capacity of the new equation was better than the existing formulas. Conclusions: We developed a formula to accurately predict daily natriuresis in the Chilean population.

Biografía del autor/a

Rodrigo A Sepúlveda, Hospital Clínico Universidad Católica – Red de Salud UC Christus, Departamento de Nefrología, Escuela de Medicina, Facultad de Medicina Pontificia Universidad Católica de Chile.

Médico Internista, Nefrólogo Magíster en Investigación en Ciencias de la Salud

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Publicado

2020-12-10

Cómo citar

Sepúlveda, R. A., Huidobro E, J. P., Jara, A., & Tagle, R. (2020). Nueva ecuación para la estimación de la natriuresis diaria a partir de parámetros en plasma y orina aislada en población chilena. Revista Médica De Chile, 149(2). Recuperado a partir de https://revistamedicadechile.cl/index.php/rmedica/article/view/8796

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Artículos de Investigación

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