D. Julius y A. Patapoutian Premios Nobel de Medicina 2021, descubren nuevos canales iónicos que detectan temperatura y estímulos mecánicos

Autores/as

  • Francisca Donoso M Universidad de Santiago de Chile
  • Pablo Sagredo M Universidad de Santiago de Chile
  • J Pablo García-Huidobro T Universidad de Santiago de Chile

Palabras clave:

Ion Channels, Nobel Prize, Physiology

Resumen

D. Julius was awarded the 2021 Medicine Nobel prize for the discovery of new cationic channels that detect temperatures either over 40 °C (TRPV1) or cold (TRPM8) ranging from 8-15 °C, followed by the latter identification of other channels that sense temperatures within other ranges. On the other hand, A. Patapoutian shared the 2021 Nobel prize for the independent and simultaneous co-discovery of the TRPM8 cationic channel. Furthermore, Patapoutian identified piezo 1 and 2 channels previously referred to as the cell mechanosensors related to the sense of touch and proprioception. These experimental findings indicate that these novel cationic channels localized in nerve endings of the skin, mouth, lips, bronchial tree, the nephron, plus a variety of tissues transduce physical stimuli into electrical activity that reach the brain sensory cortex to process these stimuli and elicit animal behavior.

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Publicado

2021-12-23

Cómo citar

Donoso M, F., Sagredo M, P., & García-Huidobro T, J. P. (2021). D. Julius y A. Patapoutian Premios Nobel de Medicina 2021, descubren nuevos canales iónicos que detectan temperatura y estímulos mecánicos. Revista Médica De Chile, 150(1). Recuperado a partir de https://revistamedicadechile.cl/index.php/rmedica/article/view/9749

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Articulo Especial